The new abstract of a position paper has now been published on F1000 with open peer review by S. Ramaswamy and I. Raikov. It explains how we need a paradigm shift from a synapse-centric theory of brain plasticity – the theory that gave us the adage “neurons that fire together wire together”- to a more biologically realistic and computationally satisfying neuron-centric theory of brain plasticity – a theory that regards the neuron as a biological cell and not just a transfer function, and that uses the full integrated capacity of the cell for plasticity, with the adage “there is room on the inside”.